Henderson is a defunct brand of U.S.-made motorcycle that went bust around the time of the Great Depression. In 1936 designer O. Ray Courtney took a 1930 Henderson and modified it into the streamlined style you see here:
Little is known about Courtney, though his name does pop up again in a 1953 Popular Science article, along with photos of another motorcycle he modded in 1950--with a style evolving along with the times:
The 1936 bike is now owned (and was restored) by one Frank Westfall of Syracuse, New York. The 1950 bike, sadly, is MIA.