If you've only got one drill, you know what a pain in the neck it is to repeatedly fasten wood without splitting it--you've got to pre-drill a hole, swap to a driver bit, drive the screw, swap back to a drill bit, then rinse and repeat. An alternative is to have both a drill and driver handy, but then you're dealing with two tools.
Luckily, design innovations are being made even in the area of basic screws: GRK Fastener's "W-Cut" screws have tips designed to act as miniature saw blades, meaning there's no pilot holes required--they'll reportedly go through four inches of lumber with no pre-drilling. "Cutting pockets" under the head mean the self-tapping screw will even countersink itself. Check 'em out here.